Cancer Research and Treatment (2025)

Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012: Seung Hoon Lee, Kyu-Won Jung, Johyun Ha, Chang-Mo Oh, Hyeseon Kim, Hyeon Jin Park, Heon Yoo, Young-Joo Won; Cancer Res Treat. 2017;49(2):494-501. Published online August 24, 2016; DOI: https://doi.org/10.4143/crt.2016.129

AbstractPDFPubReaderePub

Purpose
Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the national cancer incidence database, and to compare these rates to those in the United States and Japan.
Materials and Methods
We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korea Central Cancer Registry database. Age-standardized rates (ASRs), annual percentage change, and the male-female incidence rate ratios (IRRs) were calculated. To estimate the survival rate, we used data for patients diagnosed between 2005 and 2010 and followed their cases until December 31, 2013.
Results
The ASR for CNS GCT between 2005 and 2012 was 0.179 per 100,000 (95% confidence interval, 0.166 to 0.193), with an overall male-to-female (M:F) IRR of 2.95:1. However, when stratified by site, the M:F IRR was 13.62:1 for tumors of the pineal region and 1.87:1 for those located in nonpineal regions. The most frequent histologic type was germinoma (76.0%), and the most frequent location was the suprasellar region (48.5%). The 5-year survival rate of germinoma patients was 95.3%.
Conclusion
The incidence rate of CNS GCTs in Korea during 2005-2012 was 0.179 per 100,000, which was similar to that of the Asian/Pacific Islander subpopulation in the United States. Moreover, the CNS GCT survival rate in Korea was similar to rates in Japan and the United States.

Citations

Citations to this article as recorded by

Pediatric sellar teratoma – Case report and review of the literature
Katja Kürner, Ladina Greuter, Michel Roethlisberger, Yves Brand, Stephan Frank, Raphael Guzman, Jehuda Soleman
Child's Nervous System.2024; 40(4): 1259.CrossRef
Novel molecular subtypes of intracranial germ cell tumors expand therapeutic opportunities
Bo Li, Shuang Zhao, Shouwei Li, Chunde Li, Wei Liu, Lin Li, Bowen Cui, Xing Liu, Huiyuan Chen, Jing Zhang, Yin Ren, Fei Liu, Ming Yang, Tao Jiang, Yu Liu, Xiaoguang Qiu
Neuro-Oncology.2024; 26(7): 1335.CrossRef
Effect of delayed diagnosis on neuroendocrine function in individuals with suprasellar germ cell tumors
Tao Tong, Jian Xu, Han Chen, Caiyan Mo, Dan Liang, Liyong Zhong
Frontiers in Endocrinology.2024;[Epub]CrossRef
A deep learning model for differentiating paediatric intracranial germ cell tumour subtypes and predicting survival with MRI: a multicentre prospective study
Yanong Li, Zhizheng Zhuo, Jinyuan Weng, Sven Haller, Harrison X. Bai, Bo Li, Xing Liu, Mingwang Zhu, Zheng Wang, Jane Li, Xiaoguang Qiu, Yaou Liu
BMC Medicine.2024;[Epub]CrossRef
High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors
Yoshiko Nakano, Ian Burns, Liana Nobre, Robert Siddaway, Mansuba Rana, Cody Nesvick, Andrew Bondoc, Michelle Ku, Richard Yuditskiy, Dennis T. L. Ku, Matthew M. K. Shing, Kevin K. F. Cheng, Ho-Keung Ng, Anirban Das, Julie Bennett, Vijay Ramaswamy, Annie Hu
Acta Neuropathologica Communications.2024;[Epub]CrossRef
The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis
Nader Salari, Hooman Ghasemi, Reza Fatahian, Kamran Mansouri, Sadat Dokaneheifard, Mohammad hossain Shiri, Mahvan Hemmati, Masoud Mohammadi
European Journal of Medical Research.2023;[Epub]CrossRef
Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management
Natalia Kremenevski, Michael Buchfelder, Nirjhar Hore
Current Oncology Reports.2023; 25(7): 765.CrossRef
Diagnostik der Keimzelltumoren
Armin Bachhuber
Die Radiologie.2023; 63(8): 598.CrossRef
Methionine metabolism and endocrine function of the pituitary gland in patients with suprasellar germinoma
Hwanhee Lee, Ji Won Lee, Hee Won Cho, Yearn Seong Choe, Kyung-Han Lee, Joon Young Choi, Ki Woong Sung, Seung Hwan Moon, Liza Das
PLOS ONE.2023; 18(7): e0288528.CrossRef
The role of neoadjuvant chemotherapy in the management of metastatic central nervous system germinoma: A meta‐analysis
Mohammad H. Abu‐Arja, Margaret S. Shatara, M. Fatih Okcu, Susan L. McGovern, Jack M. Su, Mohamed S. Abdelbaki
Pediatric Blood & Cancer.2023;[Epub]CrossRef
Treatment outcomes for response-based radiotherapy in children and adolescents with central nervous system germinoma: a prospective study
Chenggong Zeng, Qunying Yang, Zhuoran Li, Zhiqing Wei, Tingting Chen, Meiling Deng, Jian Wang, Juan Wang, Feifei Sun, Junting Huang, Suying Lu, Jia Zhu, Xiaofei Sun, Zijun Zhen
Journal of Neuro-Oncology.2023; 164(3): 643.CrossRef
Intracranial Germ Cell Tumors
Teri Danielle You Ying Yeoh, Vincent Nga, Miriam Kimpo, Simon S. Lo, Balamurugan Vellayappan
Seminars in Neurology.2023; 43(06): 897.CrossRef
A Pineal Germinoma with Rapid Enlargement following Tumor Resection
Chia-Jung Hsu, Hsiang-Chih Liao, Dueng-Yuan Hueng, Kuan-Yin Tseng
Diagnostics.2023; 13(23): 3579.CrossRef
Survival outcomes, hematologic complications and growth impairment after sequential chemoradiotherapy in intracranial NGGCTs: aretrospective study
Lei Wen, Juan Li, Mingyao Lai, Zhaoming Zhou, Qingjun Hu, Guanhua Deng, Changguo Shan, Ruyu Ai, Hainan Li, Ming Lu, Liang Zhang, Taihua Wu, Dan Zhu, Yuanyuan Chen, Longhua Chen, Linbo Cai, Cheng Zhou
Strahlentherapie und Onkologie.2022; 198(5): 458.CrossRef
Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors
Wenyi Lv, Bo Li, Jin Feng, Li Chen, Xiaoguang Qiu, Shuai Liu
Health and Quality of Life Outcomes.2022;[Epub]CrossRef
Hypothalamic syndrome
Hermann L. Müller, Maithé Tauber, Elizabeth A. Lawson, Jale Özyurt, Brigitte Bison, Juan-Pedro Martinez-Barbera, Stephanie Puget, Thomas E. Merchant, Hanneke M. van Santen
Nature Reviews Disease Primers.2022;[Epub]CrossRef
A GIANT GERMINOMA MIMICS HIGH-GRADE GLIOMA: A RARE FORM OF THALAMIC REGION TUMOR
Dirga Rachmad Aprianto, Muhammad Arifin Parenrengi
Wiadomości Lekarskie.2022; 75(8): 2036.CrossRef
Clinical Outcomes and Diagnostic Consistency of Serum and CSF Tumor Markers in Pediatric Intracranial Germ Cell Tumors in Thailand: A Multicenter Study
Lalita Sathitsamitphong, Chalinee Monsereenusorn, Piti Techavichit, Kanjana Shotelersuk, Piradee Suwanpakdee, Piya Rujkijyanont, Pimlak Charoenkwan
Global Pediatric Health.2022;[Epub]CrossRef
Neurological and endocrinological manifestations of 49 children with intracranial pure germinoma at initial diagnosis in Taiwan
Hsin-Yuan Chang, Chiao-Fan Chiu, Shih-Ming Jung, Alex Mun-Ching Wong, Chieh-Tsai Wu, Fu-Sung Lo
Pediatrics & Neonatology.2021; 62(1): 106.CrossRef
Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort
Sean Stephens, Anna Kuchel, Robyn Cheuk, Hamish Alexander, Thomas Robertson, Thulasi Rajah, Quan Tran, Po-ling Inglis
Journal of Clinical Neuroscience.2021; 90: 1.CrossRef
Characteristics of growth disturbances in patients with intracranial germinomas of different origins
Bo Li, Jiayi Wang, Jiongxian Yang, Yanong Li, Yanwei Liu, Shuai Liu, Xiaoguang Qiu
Child's Nervous System.2021; 37(8): 2531.CrossRef
A clinical approach to parasellar lesions in the transition age
Emilia Sbardella, Giulia Puliani, Tiziana Feola, Riccardo Pofi, Rosa Pirchio, Franz Sesti, Federica Verdecchia, Daniele Gianfrilli, Daniel Moffat, Andrea M. Isidori, Ashley B. Grossman
Journal of Neuroendocrinology.2021;[Epub]CrossRef
Incidence and outcomes of malignant ovarian germ cell tumors in Korea, 1999–2017
Meerim Park, Jiwon Lim, Jun Ah Lee, Hyeon Jin Park, Byung Kiu Park, Myong Cheol Lim, Sang-Yoon Park, Young-Joo Won
Gynecologic Oncology.2021; 163(1): 79.CrossRef
Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae
Joo Ho Lee, Keun-Yong Eom, Ji Hoon Phi, Chul-Kee Park, Seung Ki Kim, Byung-Kyu Cho, Tae Min Kim, Dae Seog Heo, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Hee Young Shin, Seung Hong Choi, Soon Tae Lee, Sung Hye Park, Kyu-Chang Wang, Il Han Kim
Cancer Research and Treatment.2021; 53(4): 983.CrossRef
Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor
Michinari Okamoto, Shigeru Yamaguchi, Yukitomo Ishi, Hiroaki Motegi, Takashi Mori, Takayuki Hashimoto, Yukayo Terashita, Shinsuke Hirabayashi, Minako Sugiyama, Akihiro Iguchi, Yuko Cho, Atsushi Manabe, Kiyohiro Houkin
Oncology.2021; 99(1): 23.CrossRef
Symptom interval and treatment burden for patients with malignant central nervous system germ cell tumours
James Hayden, Matthew J Murray, Ute Bartels, Thankamma Ajithkumar, Brinda Muthusamy, Anthony Penn, Gabriele Calaminus, James Nicholson
Archives of Disease in Childhood.2020; 105(3): 247.CrossRef
Study Progress of Intracranial Germ Cell Tumors
晓红高
Advances in Clinical Medicine.2020; 10(03): 270.CrossRef
Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors
Takeshi Takayasu, Mauli Shah, Antonio Dono, Yuanqing Yan, Roshan Borkar, Nagireddy Putluri, Jay-Jiguang Zhu, Seiji Hama, Fumiyuki Yamasaki, Hidetoshi Tahara, Kazuhiko Sugiyama, Kaoru Kurisu, Yoshua Esquenazi, Leomar Y. Ballester
Scientific Reports.2020;[Epub]CrossRef
Canadian Pediatric Neuro-Oncology Standards of Practice
Julie Bennett, Craig Erker, Lucie Lafay-Cousin, Vijay Ramaswamy, Juliette Hukin, Magimairajan I. Vanan, Sylvia Cheng, Hallie Coltin, Adriana Fonseca, Donna Johnston, Andrea Lo, Shayna Zelcer, Saima Alvi, Lynette Bowes, Josée Brossard, Janie Charlebois, Da
Frontiers in Oncology.2020;[Epub]CrossRef
Critical review of the management of primary central nervous nongerminomatous germ cell tumors
Mohammad H. Abu Arja, Eric Bouffet, Jonathan L. Finlay, Mohamed S. AbdelBaki
Pediatric Blood & Cancer.2019;[Epub]CrossRef
Emergency irradiation of 3.4Gy/2f in pineal gland germinoma patients with symptomatic hydrocephalus
Bo Li, Youqi Li, Chunde Li, Yanwei Liu, Shuai Liu, Xiaoguang Qiu, Shiqi Luo
Chinese Neurosurgical Journal.2019;[Epub]CrossRef
A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data
Ji-Man Kang, Johyun Ha, Eun Kyung Hong, Hee Young Ju, Byung Kiu Park, Sang-Hoon Shin, Young-Joo Won, Kyu-Won Jung, Hyeon Jin Park
Cancer Epidemiology, Biomarkers & Prevention.2019; 28(2): 409.CrossRef
Central Nervous System Germ Cell Tumors: A Review of the Literature
Ziren Kong, Yaning Wang, Congxin Dai, Yong Yao, Wenbin Ma, Yu Wang
Journal of Child Neurology.2018; 33(9): 610.CrossRef

11,066View
227Download
31Web of Science
33Crossref

Population-based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009: Sang-Hoon Shin, Kyu-Won Jung, Johyun Ha, Seung Hoon Lee, Young-Joo Won, Heon Yoo; Cancer Res Treat. 2015;47(4):569-574. Published online February 12, 2015; DOI: https://doi.org/10.4143/crt.2014.085

AbstractPDFPubReaderePub

Purpose
Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor accounting for 2%-5% of all primary brain tumors. Few population-based analyses of survival for patients with PCNSL have been conducted, particularly in Asian countries. Materials and Methods Using the Korea National Cancer Incidence Database, 1,062 cases of PCNSL newly diagnosed from 1999 to 2009 were analyzed. The crude rate, age-standardized rate (ASR), and annual percent change were calculated. To estimate the observed survival, we restricted the data to between 1999 and 2007 and followed the cases until December 2010. The overall survival was estimated using the Kaplan-Meier method, and piecewise Poisson regression model.
Results
The ASR for PCNSL between 1999 and 2009 was 0.17 per 100,000, and the annual percent change from 1999 to 2009 was 8.8% (p < 0.001). The ASR of males was higher than that of females, and the older groups (60s or over) showed the largest increase in incidence rates. For all ages, the five-year survival from PCNSL was 29.9% between 1999 and 2007. Survival from PCNSL is known to show strong association with age at diagnosis. Conclusion These results are similar to those of previous studies. Our findings may be helpful to clinicians and patients in determining long-term prognoses for PCNSL.

Citations

Citations to this article as recorded by

All-cause and tumor-specific mortality trends in elderly primary central nervous system lymphoma (PCNSL) patients: a surveillance, epidemiology, and end results (SEER) analysis
Taylor FURST, Haydn HOFFMAN, Lawrence S. CHIN
Journal of Neurosurgical Sciences.2024;[Epub]CrossRef
Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma
Raphael Reinecke, Kolja Jahnke, Martha Foltyn‐Dumitru, Karsten Lachner, Moritz Armbrust, Katharina J. Weber, Pia S. Zeiner, Marcus Czabanka, Uta Brunnberg, Sylvia Hartmann, JoachimP. Steinbach, Michael W. Ronellenfitsch
Journal of Neurochemistry.2024; 168(6): 1157.CrossRef
Targeting the tumor microenvironment in primary central nervous system lymphoma: Implications for prognosis
Han Shi, Xuefei Sun, Yuchen Wu, Qu Cui, Shengjun Sun, Nan Ji, Yuanbo Liu
Journal of Clinical Neuroscience.2024; 124: 36.CrossRef
Long term outcomes in older patients with primary central nervous system lymphoma: an analysis of the Texas Cancer Registry
Ethan A. Burns, Cesar Gentille Sanchez, Sunil Mathur, Carlo Guerrero, Ibrahim N. Muhsen, Humaira Sarfraz, Chih-Chi Andrew Hu, Chih-Hang Anthony Tang, Shilpan S. Shah, Ivo W. Tremont, Bin Teh, Siddhartha Ganguly, Sai Ravi Kiran Pingali
Annals of Hematology.2023; 102(5): 1111.CrossRef
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
Yao Hu, Qingyun Zhang, Zhiyuan Wu, Kun Chen, Xiao Xu, Weizhe Ma, Bobin Chen, Limin Jin, Ming Guan
Discover Oncology.2023;[Epub]CrossRef
Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis
Inka Puhakka, Hanne Kuitunen, Pekka Jäkälä, Eila Sonkajärvi, Taina Turpeenniemi-Hujanen, Aino Rönkä, Tuomas Selander, Miika Korhonen, Outi Kuittinen
BMC Cancer.2022;[Epub]CrossRef
Use of rituximab, temozolomide, and radiation in recurrent and refractory primary central nervous system lymphoma in the Philippines: a retrospective analysis
Julette Marie F Batara, Almira Doreen Abigail O Apor, Christianne V Mojica, Mark Willy L Mondia
Neuro-Oncology Advances.2022;[Epub]CrossRef
The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper
Justine R Smith, Alexandra L Farrall, Janet L Davis, Joke H de Boer, Anthony J Hall, Manabu Mochizuki, H Nida Sen, Hiroshi Takase, Ninette H ten Dam-van Loon, Valérie Touitou, Daniel V Vasconcelos-Santos, David J Wilson, Steven Yeh, Mark H B Radford
BMJ Open.2022; 12(7): e060701.CrossRef
Changing Incidence and Survival of Primary Central Nervous System Lymphoma in Australia: A 33-Year National Population-Based Study
Alexandra L. Farrall, Justine R. Smith
Cancers.2021; 13(3): 403.CrossRef
Eye involvement in primary central nervous system lymphoma
Alexandra L. Farrall, Justine R. Smith
Survey of Ophthalmology.2020; 65(5): 548.CrossRef
Characteristics, management and outcome of DLBCL patients, presenting with simultaneous systemic and CNS disease at diagnosis: A retrospective multicenter study
Chava Perry, Sharon Ben Barouch, Neta Goldschmidt, Nadav Sarid, Yair Herishanu, Lev Shvidel, Osnat Bairey, Noa Lavi, Netanel Horowitz, Avraham Avigdor, Eyal Lebel, Orit Sofer, Ron Ram, Irit Avivi
American Journal of Hematology.2019; 94(9): 992.CrossRef
Improved survival in primary central nervous system lymphoma up to age 70 only: a population-based study on incidence, primary treatment and survival in the Netherlands, 1989–2015
M van der Meulen, A G Dinmohamed, O Visser, J K Doorduijn, J E C Bromberg
Leukemia.2017; 31(8): 1822.CrossRef
Role of radiation therapy in primary central nervous system lymphoma
Hyeon Kang Koh, Il Han Kim, Tae Min Kim, Do Hoon Lim, Dongryul Oh, Jae Ho Cho, Woo-Chul Kim, Jin Hee Kim, Woong-Ki Chung, Bae-Kwon Jeong, Ki Mun Kang, Semie Hong, Chang-Ok Suh, In Ah Kim
Journal of Neuro-Oncology.2017; 135(3): 629.CrossRef

12,452View
115Download
14Web of Science
13Crossref

Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells: Guk Heui Jo, Oliver Bögler, Yong-Joon Chwae, Heon Yoo, Seung Hoon Lee, Jong Bae Park, Youn-Jae Kim, Jong Heon Kim, Ho-Shin Gwak; Cancer Res Treat. 2015;47(2):221-241. Published online August 29, 2014; DOI: https://doi.org/10.4143/crt.2013.159

AbstractPDFPubReaderePub

Purpose
Radiation-induced autophagy has been shown to play two different roles, in malignant glioma (MG) cells, cytocidal or cytoprotective. However, neither the role of radiation-induced autophagy for cell death nor the existence of autophagy-induced apoptosis, a well-known cell-death pathway after irradiation, has been verified yet. Materials and Methods We observed both temporal and dose-dependent response patterns of autophagy and apoptosis to radiation in MG cell lines. Additionally, we investigated the role of autophagy in apoptosis through knockdown of autophagy-related proteins. Results Autophagic activity measured by staining of acidic vesicle organelles and Western blotting of LC-3 protein increased in proportion to radiation dose from day 1 to 5 after irradiation. Apoptosis measured by annexin-V staining and Western blotting of cleaved poly(ADP-ribose) polymerase demonstrated relatively late appearance 3 days after irradiation that increased for up to 7 days. Blocking of pan-caspase (Z-VAD-FMK) did not affect apoptosis after irradiation, but silencing of Atg5 effectively reduced radiation-induced autophagy, which decreased apoptosis significantly. Inhibition of autophagy in Atg5 knockdown cells was shown to be beneficial for cell survival. Stable transfection of GFP-LC3 cells was observed after irradiation. Annexin-V was localized in cells bearing GFP-LC3 punctuated spots, indicating autophagy in immunofluorescence. Some of these punctuated GFP-LC3 bearing cells formed conglomerated spots and died in final phase. Conclusion These findings suggest that autophagy appears earlier than apoptosis after irradiation and that a portion of the apoptotic population that appears later is autophagy-dependent. Thus, autophagy is a pathway to cell death after irradiation of MG cells.

Citations

Citations to this article as recorded by

Autophagy in glioblastoma: A mechanistic perspective
Durgesh Meena, Sushmita Jha
International Journal of Cancer.2024; 155(4): 605.CrossRef
Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia
Rhianna M. Hill, Chun Li, Jonathan R. Hughes, Sonia Rocha, Gabrielle J. Grundy, Jason L. Parsons
Journal of Cellular and Molecular Medicine.2024;[Epub]CrossRef
The reversibility of cancer radioresistance: a novel potential way to identify factors contributing to tumor radioresistance
Yoshikazu Kuwahara, Kazuo Tomita, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Tomoaki Sato, Akihiro Kurimasa
Human Cell.2023; 36(3): 963.CrossRef
The role of autophagy in hypoxia-induced radioresistance
Rhianna Mae Hill, Matthew Fok, Gabrielle Grundy, Jason Luke Parsons, Sonia Rocha
Radiotherapy and Oncology.2023; 189: 109951.CrossRef
Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats
Jin-Cherng Chen, Juen-Haur Hwang
Nutrition and Cancer.2022; 74(3): 1090.CrossRef
ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model
Jung Mo Lee, Hey Soo Kim, Arum Kim, Yoon Soo Chang, Jin Gu Lee, Jaeho Cho, Eun Young Kim
Yonsei Medical Journal.2022; 63(1): 16.CrossRef
Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin
Meng Wang, Fan Zhan, Hui Cheng, Qinglin Li
Biological and Pharmaceutical Bulletin.2022; 45(1): 63.CrossRef
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
Annabella F. Thomas, Gemma L. Kelly, Andreas Strasser
Cell Death & Differentiation.2022; 29(5): 961.CrossRef
Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?
Juliana B. Vilar, Markus Christmann, Maja T. Tomicic
Cancers.2022; 14(10): 2416.CrossRef
Repurposing autophagy regulators in brain tumors
Edgar Petrosyan, Jawad Fares, Alex Cordero, Aida Rashidi, Víctor A. Arrieta, Deepak Kanojia, Maciej S. Lesniak
International Journal of Cancer.2022; 151(2): 167.CrossRef
Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKT degradation through autophagy flux
Hyo Jeong Kim, Sun-Yong Kim, Dae-Ho Kim, Joon Seong Park, Seong Hyun Jeong, Young Won Choi, Chul-Ho Kim
Autophagy.2021; 17(4): 961.CrossRef
Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma
Imran Khan, Mohammad Hassan Baig, Sadaf Mahfooz, Moniba Rahim, Busra Karacam, Elif Burce Elbasan, Ilya Ulasov, Jae-June Dong, Mustafa Aziz Hatiboglu
International Journal of Molecular Sciences.2021; 22(3): 1318.CrossRef
Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy?
Thijs A. van Schaik, Kok-Siong Chen, Khalid Shah
Frontiers in Oncology.2021;[Epub]CrossRef
Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis
Don Carlo Ramos Batara, Moon-Chang Choi, Hyeon-Uk Shin, Hyunggee Kim, Sung-Hak Kim
Cells.2021; 10(6): 1411.CrossRef
Breaking Bad: Autophagy Tweaks the Interplay Between Glioma and the Tumor Immune Microenvironment
Yuxiang Fan, Yubo Wang, Jian Zhang, Xuechao Dong, Pu Gao, Kai Liu, Chengyuan Ma, Gang Zhao
Frontiers in Immunology.2021;[Epub]CrossRef
Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition
Giuseppina Raspaglio, Marianna Buttarelli, Flavia Filippetti, Alessandra Battaglia, Alexia Buzzonetti, Giovanni Scambia, Daniela Gallo
Cell Death & Disease.2021;[Epub]CrossRef
HMGB1 mediated autophagy protects glioblastoma cells from carbon-ion beam irradiation injury
Runhong Lei, Liben Yan, Yulin Deng, Jin Xu, Tuo Zhao, M. Umer Farooq Awan, Qiang Li, Guangming Zhou, Xiao Wang, Hong Ma
Acta Astronautica.2020; 166: 628.CrossRef
Autophagy as a Potential Therapy for Malignant Glioma
Angel Escamilla-Ramírez, Rosa A. Castillo-Rodríguez, Sergio Zavala-Vega, Dolores Jimenez-Farfan, Isabel Anaya-Rubio, Eduardo Briseño, Guadalupe Palencia, Patricia Guevara, Arturo Cruz-Salgado, Julio Sotelo, Cristina Trejo-Solís
Pharmaceuticals.2020; 13(7): 156.CrossRef
Nano delivery of natural substances as prospective autophagy modulators in glioblastoma
Srishti Agarwal, Toru Maekawa
Nanomedicine: Nanotechnology, Biology and Medicine.2020; 29: 102270.CrossRef
Elucidation of gastrointestinal dysfunction in response to irradiation using metabolomics
Mohammed Salah, Saki Osuga, Makiko Nakahana, Yasuhiro Irino, Masakazu Shinohara, Yasuyuki Shimizu, Naritoshi Mukumoto, Hiroaki Akasaka, Ai Nakaoka, Daisuke Miyawaki, Takeaki Ishihara, Kenji Yoshida, Yoshiaki Okamoto, Ryohei Sasaki
Biochemistry and Biophysics Reports.2020; 23: 100789.CrossRef
The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation
Nipa H. Patel, Sahib S. Sohal, Masoud H Manjili, J. Chuck Harrell, David A. Gewirtz
Radiation Research.2020; 194(2): 103.CrossRef
Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells
Alfred Komakech, Ji-Hye Im, Ho-Shin Gwak, Kyue-Yim Lee, Jong Heon Kim, Byong Chul Yoo, Heesun Cheong, Jong Bae Park, Ji Woong Kwon, Sang Hoon Shin, Heon Yoo
Journal of Korean Neurosurgical Society.2020; 63(5): 566.CrossRef
Inhibition of Endoplasmic Reticulum Stress-Mediated Autophagy Enhances the Anticancer Effect of Iodine-125 Seed Radiation on Esophageal Squamous Cell Carcinoma
Chao Wang, Tian-Kuan Li, Chu-Hui Zeng, Jian Yang, Yong Wang, Jian Lu, Guang-Yu Zhu, Jin-He Guo
Radiation Research.2020; 194(3): 236.CrossRef
Therapeutic Potential of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors
Qin Xia, Mengchuan Xu, Pei Zhang, Liqun Liu, Xinyi Meng, Lei Dong
Frontiers in Oncology.2020;[Epub]CrossRef
Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention
Md. Ataur Rahman, MD. Hasanur Rahman, Md. Shahadat Hossain, Partha Biswas, Rokibul Islam, Md Jamal Uddin, Md. Habibur Rahman, Hyewhon Rhim
Biomedicines.2020; 8(11): 517.CrossRef
High LC3/Beclin Expression Correlates with Poor Survival in Glioma: a Definitive Role for Autophagy as Evidenced by In Vitro Autophagic Flux
Padmakrishnan CJ, Easwer HV, Vinod Vijayakurup, Girish R Menon, Suresh Nair, Srinivas Gopala
Pathology & Oncology Research.2019; 25(1): 137.CrossRef
Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in Colorectal Cancer Cells
Sang Yoon Park, Seon-Jin Lee, Hee Jun Cho, Jong-Tae Kim, Hyang Ran Yoon, Kyung Ho Lee, Bo Yeon Kim, Younghee Lee, Hee Gu Lee
Cancers.2019; 11(4): 498.CrossRef
NOS2 inhibitor 1400W Induces Autophagic Flux and Influences Extracellular Vesicle Profile in Human Glioblastoma U87MG Cell Line
Paola Palumbo, Francesca Lombardi, Francesca Rosaria Augello, Ilaria Giusti, Sabino Luzzi, Vincenza Dolo, Maria Grazia Cifone, Benedetta Cinque
International Journal of Molecular Sciences.2019; 20(12): 3010.CrossRef
Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma
Sushant Lakkadwala, Bruna dos Santos Rodrigues, Chengwen Sun, Jagdish Singh
Journal of Controlled Release.2019; 307: 247.CrossRef
Glioblastoma: Targeting the autophagy in tumorigenesis
Kang Yang, Long Niu, Yijing Bai, Weidong Le
Brain Research Bulletin.2019; 153: 334.CrossRef
Radiotherapy of meningioma: a treatment in need of radiobiological research
Valentina Pinzi, Ilaria Bisogno, Francesco Prada, Emilio Ciusani, Laura Fariselli
International Journal of Radiation Biology.2018; 94(7): 621.CrossRef
Radiation, inflammation and the immune response in cancer
Kelly J. McKelvey, Amanda L. Hudson, Michael Back, Tom Eade, Connie I. Diakos
Mammalian Genome.2018;[Epub]CrossRef
Association between radiation-induced cell death and clinically relevant radioresistance
Yoshikazu Kuwahara, Kazuo Tomita, Yusuke Urushihara, Tomoaki Sato, Akihiro Kurimasa, Manabu Fukumoto
Histochemistry and Cell Biology.2018; 150(6): 649.CrossRef
Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma
Cristina Trejo-Solís, Norma Serrano-Garcia, Ángel Escamilla-Ramírez, Rosa A. Castillo-Rodríguez, Dolores Jimenez-Farfan, Guadalupe Palencia, Minerva Calvillo, Mayra A. Alvarez-Lemus, Athenea Flores-Nájera, Arturo Cruz-Salgado, Julio Sotelo
International Journal of Molecular Sciences.2018; 19(12): 3773.CrossRef
Effects of ionizing radiation on the viability and proliferative behavior of the human glioblastoma T98G cell line
Hossam Murad, Yaman Alghamian, Abdulmunim Aljapawe, Ammar Madania
BMC Research Notes.2018;[Epub]CrossRef
Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells
Xiaoxing Liu, Haiyan Chen, Xin Xu, Ming Ye, Hongbin Cao, Lei Xu, Yanli Hou, Jianmin Tang, Di Zhou, Yongrui Bai, Xiumei Ma
Oncology Letters.2018;[Epub]CrossRef
Radiotherapy and immune response: the systemic effects of a local treatment
Heloisa de Andrade Carvalho, Rosangela Correa Villar
Clinics.2018; 73: e557s.CrossRef
Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness
Qiuji Wu, Awatef Allouch, Isabelle Martins, Catherine Brenner, Nazanine Modjtahedi, Eric Deutsch, Jean-Luc Perfettini
Frontiers in Immunology.2017;[Epub]CrossRef
Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy
Ying-Ying Li, Lynn Feun, Angkana Thongkum, Chiao-Hui Tu, Shu-Mei Chen, Medhi Wangpaichitr, Chunjing Wu, Macus Kuo, Niramol Savaraj
International Journal of Molecular Sciences.2017; 18(6): 1297.CrossRef
Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams
Luwei Zhang, Jiawei Yan, Yang Liu, Qiuyue Zhao, Cuixia Di, Sun Chao, Li Jie, Yuanyuan Liu, Hong Zhang
Oncology Reports.2017; 37(5): 2994.CrossRef
BAMBI overexpression together with β-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-β/Smad2/3 pathway
Xingchun Wang, Minjie Li, Mengyao Hu, Ping Wei, Wei Zhu
Oncology Reports.2017; 37(5): 3046.CrossRef
The Impact of Non-Lethal Single-Dose Radiation on Tumor Invasion and Cytoskeletal Properties
Tim Hohmann, Urszula Grabiec, Carolin Vogel, Chalid Ghadban, Stephan Ensminger, Matthias Bache, Dirk Vordermark, Faramarz Dehghani
International Journal of Molecular Sciences.2017; 18(9): 2001.CrossRef
Influence of gap junction intercellular communication composed of connexin 43 on the antineoplastic effect of adriamycin in breast cancer cells
Guojun Jiang, Shuying Dong, Meiling Yu, Xi Han, Chao Zheng, Xiaoguang Zhu, Xuhui Tong
Oncology Letters.2017; 13(2): 857.CrossRef
To live or let die: Unclear task of autophagy in the radiosensitization battle
Martin Ondrej, Lucie Cechakova, Kamila Durisova, Jaroslav Pejchal, Ales Tichy
Radiotherapy and Oncology.2016; 119(2): 265.CrossRef
Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress
ZHONGLIANG WANG, TINGTING DU, XIAORONG DONG, ZHENYU LI, GANG WU, RUIGUANG ZHANG
International Journal of Oncology.2016; 48(6): 2558.CrossRef
Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy
Feven Tameire, Ioannis I. Verginadis, Constantinos Koumenis
Seminars in Cancer Biology.2015; 33: 3.CrossRef
Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy
Byeong Kim, Yunkyung Hong, Seunghoon Lee, Pengda Liu, Ji Lim, Yong Lee, Tae Lee, Kyu Chang, Yonggeun Hong
International Journal of Molecular Sciences.2015; 16(11): 26880.CrossRef

19,295View
249Download
53Web of Science
47Crossref

Incidence of Primary Spinal Cord, Spinal Meninges, and Cauda Equina Tumors in Korea, 2006-2010: Kyu-Won Jung, Kwang Hyon Park, Johyun Ha, Seung Hoon Lee, Young-Joo Won, Heon Yoo; Cancer Res Treat. 2015;47(2):166-172. Published online October 30, 2014; DOI: https://doi.org/10.4143/crt.2014.017

AbstractPDFPubReaderePub

Purpose
Primary spinal cord and appendage tumors (PSCAT) originating from the spinal cord, spinal meninges, and cauda equina are uncommon. Worldwide, population-based cancer registry data are mostly based on malignant tumors only, which means few data are available on PSCATs, including non-malignant tumors. Therefore, the objective of this study was to provide information regarding the incidence of both non-malignant and malignant PSCATs in Korea on a national level. Materials and Methods Incidence of PSCATs was estimated from cases diagnosed between 2006 and 2010 using the National Cancer Incidence Database in Korea. Age-adjusted rates were calculated using the world standard population, and male-to-female rate ratios were calculated by histology type. Results Of all PSCATs registered (n=3,312), 86.6% were non-malignant. The overall age-adjusted incidence of PSCATs was 1.08 per 100,000 person-years, with an incidence of 0.99 per 100,000 in females and 1.15 in males. The most common site of PSCATs was the spinal cord (83.4%), followed by spinal meninges (16.1%) and cauda equina (0.5%). The most common histological type was neurilemmoma (41.3%), followed by meningiomas (20.1%) and ependymomas (7.6%). Men had significantly higher rates than women for ependymomas and lymphomas but had lower rates for meningiomas. Conclusion This study provides the first population-based analysis of PSCATs in Korea.

Citations

Citations to this article as recorded by

Multiple Medullary Schwannoma Associated with Lumbar Disc Herniation and Cauda Equina Syndrome: Case Report
Anibal Rodrigues Neto, Bianca Bicalho, Giovanna Maria Varandas, Adriano Torres Antonucci, Gabriel Gomes Freitas de Castro, Shiro Manoel Shimoakoishi de Arruda, Marcel Schiavini, Lutero Cleuler Moraes dos Santos, Márcio Francisco Lehmann, Francisco Spessat
Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery.2024; 43(02): e117.CrossRef
Surgical Strategy for Dumbbell-Shaped Cervical Schwannoma at the Vicinity of the Vertebral Artery: The Utilization of Anatomic Layer
Hangeul Park, Sum Kim, Young-Rak Kim, Sung-Hye Park, John M. Rhee, Chun Kee Chung, Jun-Hoe Kim, Chang-Hyun Lee, Kyoung-Tae Kim, Chi Heon Kim
Operative Neurosurgery.2024;[Epub]CrossRef
Is laminectomy necessary for C1-C2 epidural schwannomas?
Tae-Shin Kim, Woon Tak Yuh, Junghoon Han, Junhoe Kim, Chang-Hyun Lee, Chi Heon Kim, Chun Kee Chung
Acta Neurochirurgica.2023; 165(10): 3065.CrossRef
Primary Benign Tumors of the Spinal Canal
José Alberto Carlos-Escalante, Ángel Antonio Paz-López, Bernardo Cacho-Díaz, Guillermo Pacheco-Cuellar, Gervith Reyes-Soto, Talia Wegman-Ostrosky
World Neurosurgery.2022; 164: 178.CrossRef
Spinal biopsies: a clinicopathologic review of 53 cases diagnosed between 2011 and 2018 at a tertiary hospital in Kampala, Uganda
James J. Yahaya
Egyptian Journal of Neurosurgery.2021;[Epub]CrossRef
Racial and Ethnic Disparities in the Inpatient Management of Primary Spinal Cord Tumors
Ryan G. Chiu, Blake E. Murphy, Amy Zhu, Ankit I. Mehta
World Neurosurgery.2020; 140: e175.CrossRef
Primary Central Nerve System Lymphoma Affecting the Lumbosacral Nerve Root: A Case Report
Junhyung Kim, Bonggyu Ryu, Seung-Jae Hyun, Ki-Jeong Kim
The Nerve.2020; 6(2): 110.CrossRef
Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics
Rachel E. Tsolinas, John F. Burke, Anthony M. DiGiorgio, Leigh H. Thomas, Xuan Duong-Fernandez, Mark H. Harris, John K. Yue, Ethan A. Winkler, Catherine G. Suen, Lisa U. Pascual, Adam R. Ferguson, J. Russell Huie, Jonathan Z. Pan, Debra D. Hemmerle, Vinee
Neurosurgical Focus.2020; 48(5): E6.CrossRef
A Nation-Wide Epidemiological Study of Newly Diagnosed Primary Spine Tumor in the Adult Korean Population, 2009-2011
Seil Sohn, Jinhee Kim, Chun Kee Chung, Na Rae Lee, Moon Jun Sohn, Sung Hwan Kim
Journal of Korean Neurosurgical Society.2017; 60(2): 195.CrossRef
Nationwide epidemiology and healthcare utilization of spine tumor patients in the adult Korean population, 2009–2012
Seil Sohn, Jinhee Kim, Chun Kee Chung, Na-Rye Lee, Eunjung Park, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim
Neuro-Oncology Practice.2015; 2(2): 93.CrossRef

10,710View
99Download
10Web of Science
10Crossref

Surgical Outcomes of Hemorrhagic Metastatic Brain Tumors: Heon Yoo, Eugene Jung, Ho Shin Gwak, Sang Hoon Shin, Seung Hoon Lee; Cancer Res Treat. 2011;43(2):102-107. Published online June 30, 2011; DOI: https://doi.org/10.4143/crt.2011.43.2.102

AbstractPDFPubReaderePub

PURPOSE
Hemorrhagic metastatic brain tumors are not rare, but little is known about the surgical outcome following treatment. We conducted this study to determine the result of the surgical outcome of hemorrhagic metastatic brain tumors.
MATERIALS AND METHODS
From July 2001 to December 2008, 21 patients underwent surgery for hemorrhagic metastatic brain tumors at our institution. 15 patients had lung cancer, 3 had hepatocellular carcinoma, and the rest had rectal cancer, renal cell carcinoma, and sarcoma. 20 patients had macroscopic hemorrhage in the tumors, and one patient had intracerebral hemorrhage surrounding the tumor. A retrospective clinical review was conducted focusing on the patterns of presenting symptoms and signs, as well as local recurrence following surgery.
RESULTS
Among 21 hemorrhagic brain metastases, local recurrence developed in two patients. The 12 month progression free survival rate was 86.1%. Mean time to progression was 20.8 months and median survival time after surgery was 11.7 months.
CONCLUSION
The results of our study showed that hemorrhagic metastatic brain tumors rarely recurred after surgery.Surgery should be considered as a good treatment option for hemorrhagic brain metastasis, especially in cases with increased intracranial pressure or severe neurologic deficits.

Citations

Citations to this article as recorded by

Predictors and surgical outcome of hemorrhagic metastatic brain malignancies
Laurèl Rauschenbach, Pia Kolbe, Adrian Engel, Yahya Ahmadipour, Marvin Darkwah Oppong, Alejandro N. Santos, Sied Kebir, Celia Dobersalske, Björn Scheffler, Cornelius Deuschl, Philipp Dammann, Karsten H. Wrede, Ulrich Sure, Ramazan Jabbarli
Journal of Neuro-Oncology.2024; 169(1): 165.CrossRef
Should we be afraid of radiotherapy for hemorrhagic brain metastases? A narrative review
Aleksandra Łupicka, Weronika Kowalczyk, Bartosz Cyman, Mateusz Spałek
Therapeutic Advances in Medical Oncology.2024;[Epub]CrossRef
Hemorrhagic brain metastasis from small-cell carcinoma of the urinary bladder
Kazuhide Maeshima, Takahiro Sasaki, Toshikazu Yamoto, Junya Fukai, Hiroki Nishibayashi, Naoyuki Nakao
Surgical Neurology International.2022; 13: 20.CrossRef
Hemorrhage in brain tumor – An unresolved issue
Robert P. Ostrowski, Zhaohui He, Emanuela B. Pucko, Ewa Matyja
Brain Hemorrhages.2022; 3(2): 98.CrossRef
Cardiac Angiosarcomas
Andrew J. Bishop, Jing Zheng, Aparna Subramaniam, Amol J. Ghia, Chenyang Wang, Susan L. McGovern, Shreyaskumar Patel, B. Ashleigh Guadagnolo, Devarati Mitra, Ahsan Farooqi, Michael J. Reardon, Betty Kim, Nandita Guha-Thakurta, Jing Li, Vinod Ravi
American Journal of Clinical Oncology.2022; 45(6): 258.CrossRef
Correlation Analysis between Retention of Gd-DTPA in the Cystic Area of Brain Metastasis and MRI Signs
Jili Wang, Shanshan Qu, Qinyan Xu, Zhaofeng Jin, Tian Li, Shuxian Zhang, Xihe Sun, Qingbin Cui
Journal of Oncology.2022; 2022: 1.CrossRef
Efficacy of BRAF Inhibitors in Combination With Stereotactic Radiosurgery for the Treatment of Melanoma Brain Metastases: A Systematic Review and Meta-Analysis
Muhammad Khan, Tao Zheng, Zhihong Zhao, Sumbal Arooj, Guixiang Liao
Frontiers in Oncology.2021;[Epub]CrossRef
Management of patients suffering from hemorrhagic intracranial metastases: Propositions to help the neurosurgeon in emergency situations based on a literature review
S. Boissonneau, T. Graillon, A. Rolland, C. Botella, J. Pallud, H. Dufour
Neurochirurgie.2021; 67(4): 369.CrossRef
3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography
Elena Longo, Lucie Sancey, Alessia Cedola, Emmanuel L. Barbier, Alberto Bravin, Francesco Brun, Inna Bukreeva, Michela Fratini, Lorenzo Massimi, Imke Greving, Geraldine Le Duc, Olivier Tillement, Ombeline De La Rochefoucauld, Philippe Zeitoun
Frontiers in Oncology.2021;[Epub]CrossRef
Critical cerebellar hemorrhage due to pilocytic astrocytoma in a child: A case report
Akihiko Teshigawara, Toshikazu Kimura, Shunsuke Ichi
Surgical Neurology International.2021; 12: 448.CrossRef
Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis
Motaz Hamed, Niklas Schäfer, Christian Bode, Valeri Borger, Anna-Laura Potthoff, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Muriel Heimann, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Elisa Scharnböck, Christina Schaub, Kat
Frontiers in Oncology.2021;[Epub]CrossRef
Molecular and immunological associations of elevated serum lactate dehydrogenase in metastatic melanoma patients: A fresh look at an old biomarker
Grant M. Fischer, Fernando C. L. Carapeto, Aron Y. Joon, Lauren E. Haydu, Huiqin Chen, Fuchenchu Wang, John S. Van Arnam, Jennifer L. McQuade, Khalida Wani, John M. Kirkwood, John F. Thompson, Michael T. Tetzlaff, Alexander J. Lazar, Hussein A. Tawbi, Jef
Cancer Medicine.2020; 9(22): 8650.CrossRef
Over-expression of S100B protein as a serum marker of brain metastasis in non-small cell lung cancer and its prognostic value
Lijuan Chen, Xiufeng Hu, Huijuan Wu, Yongxu Jia, Jie Liu, Xiaoqian Mu, Hongbo Wu, Yanqiu Zhao
Pathology - Research and Practice.2019; 215(3): 427.CrossRef
La radiothérapie en conditions stéréotaxiques des métastases cérébrales en situation complexe
G. Noel, A. Keller, D. Antoni
Cancer/Radiothérapie.2019; 23(6-7): 708.CrossRef
Multiple massive intratumoral hemorrhages of metastatic brain melanoma after ventriculoperitoneal shunt
Tsung-Hsi Yang, Jung-Tung Liu, Fook-How Chan
Formosan Journal of Surgery.2019; 52(3): 99.CrossRef
Two Cases of Metastatic Malignant Melanoma
Keijiro Hara, Kazuhiro Hirano, Yukari Ogawa, Keita Kinoshita, Satoshi Hirai, Hiroki Takai, Nobuhisa Matsushita, Hiroyuki Toi, Hirotake Nishimura, Ryo Tanaka, Shunji Matsubara, Masaaki Uno
Japanese Journal of Neurosurgery.2018; 27(5): 393.CrossRef
Stereotactic radiosurgery for brain metastases from malignant melanoma and the impact of hemorrhagic metastases
Kristine Bauer-Nilsen, Daniel M. Trifiletti, Ajay Chatrath, Henry Ruiz-Garcia, Eduardo Marchan, Jennifer Peterson, Byron C. May, Jason P. Sheehan
Journal of Neuro-Oncology.2018; 140(1): 83.CrossRef
Posterior Fossa Metastasis–Associated Obstructive Hydrocephalus in Adult Patients: Literature Review and Practical Considerations from the Neuro-Oncology Club of the French Society of Neurosurgery
Alexandre Roux, Céline Botella, Megan Still, Marc Zanello, Frédéric Dhermain, Philippe Metellus, Johan Pallud
World Neurosurgery.2018; 117: 271.CrossRef
Cerebellar hemorrhage due to dural arteriovenous fistula mimicking a hemorrhagic metastatic brain tumor: a case report
Yoichi Yoshida, Yoshinori Higuchi, Ryota Nomura, Shiro Ikegami, Toshimasa Shin, Ayaka Hara, Taiki Setoguchi, Eiichi Kobayashi, Kazuhiro Nomoto, Yasuo Iwadate
Nosotchu.2018; 40(6): 427.CrossRef
Risk of Cerebrovascular Events in 178 962 Five-Year Survivors of Cancer Diagnosed at 15 to 39 Years of Age
Chloe J. Bright, Mike M. Hawkins, Joyeeta Guha, Katherine E. Henson, David L. Winter, Julie S. Kelly, Richard G. Feltbower, Marlous Hall, David J. Cutter, Angela B. Edgar, Clare Frobisher, Raoul C. Reulen
Circulation.2017; 135(13): 1194.CrossRef
Hemorrhage of brain metastasis is a poor prognostic factor in hepatocellular carcinoma patients
Yan Lin, Shi-Ting Huang, Yan-Ming Jiang, Xin-Bin Pan
Oncotarget.2017; 8(54): 93245.CrossRef
Pointing to the Diagnosis: Hemorrhagic Brain Metastasis
Yu-Hsiang Juan, Huei-Fang Hsuan, Yun-Chung Cheung, Shu-Hang Ng, Koon-Kwan Ng, Chin-Wei Yu, Yu-Ying Cheng, Yu-Ching Lin
The American Journal of Medicine.2016; 129(12): 1268.CrossRef
Anesthetic Management of Supratentorial Tumors
Abirami Kumaresan, Ekkehard Kasper, Ruma Bose
International Anesthesiology Clinics.2015; 53(1): 74.CrossRef
Brain Metastasis From Papillary Thyroid Carcinoma in a Seventy-Three-Year-Old Man
Babak Alijani, Mohammad Reza Emamhadi, Shahrokh Yousefzadeh Chabok, Hamid Behzadnia, Siavash Dehghani
Archives of Neuroscience.2015;[Epub]CrossRef
Post-treatment intracranial hemorrhage of brain metastases from hepatocellular carcinoma
Kyung Su Kim, Kyubo Kim, Eui Kyu Chie, Yoon Jun Kim, Jung Hwan Yoon, Hyo-Suk Lee, Sung W. Ha
Radiation Oncology Journal.2015; 33(1): 36.CrossRef
Bevacizumab in Patients with Nonsquamous Non–Small Cell Lung Cancer and Asymptomatic, Untreated Brain Metastases (BRAIN): A Nonrandomized, Phase II Study
Benjamin Besse, Sylvestre Le Moulec, Julien Mazières, Hélène Senellart, Fabrice Barlesi, Christos Chouaid, Eric Dansin, Henri Bérard, Lionel Falchero, Radj Gervais, Gilles Robinet, Anne-Marie Ruppert, Roland Schott, Hervé Léna, Christelle Clément-Duchêne,
Clinical Cancer Research.2015; 21(8): 1896.CrossRef

16,664View
140Download
26Crossref

Radiation-induced Necrosis Deteriorating Neurological Symptoms and Mimicking Progression of Brain Metastasis after Stereotactic-guided Radiotherapy: Young Zoon Kim, Dae Yong Kim, Heon Yoo, Hee Seok Yang, Sang Hoon Shin, Eun Kyung Hong, Kwan Ho Cho, Seung Hoon Lee; Cancer Res Treat. 2007;39(1):16-21. Published online March 31, 2007; DOI: https://doi.org/10.4143/crt.2007.39.1.16

AbstractPDFPubReaderePub

Purpose

Although radiation-induced necrosis (RIN) is not a tumor in itself, the lesion progressively enlarges with mass effects and diffuse peritumoral edema in a way that resembles neoplasm. To identify the RIN that mimics progression of brain metastasis, we performed surgical resections of symptomatic RIN lesions.

Meterials and Methods

From June 2003 to December 2005, 7 patients received stereotactic-guided radiotherapy (SRT) for metastatic brain tumor, and they later underwent craniotomy and tumor resection due to the progressive mass effects and the peritumoral edema that caused focal neurological deficit. On MR imaging, a ring-like enhanced single lesion with massive peritumoral edema could not be distinguished from progression of brain metastasis.

Results

Four patients had non-small cell lung cancer, 2 patients had colorectal cancer and 1 patient had renal cell carcinoma. The mean tumor volume was 8.7 ml (range: 3.0~20.7 ml). The prescribed dose of SRT was 30 Gy with 4 fractions for one patient, 18 Gy for two patients and 20 Gy for the other four patients. The four patients who received SRT with a dose of 20 Gy had RIN with or without microscopic residual tumor cells.

Conclusions

Early detection of recurrent disease after radiotherapy and identifying radiation-induced tissue damage are important for delivering adequate treatment. Therefore, specific diagnostic tools that can distinguish RIN from progression of metastatic brain tumor need to be developed.

Citations

Citations to this article as recorded by

Salvage craniotomy for treatment-refractory symptomatic cerebral radiation necrosis
Ashish H Shah, Anil K Mahavadi, Alexis Morell, Daniel G Eichberg, Evan Luther, Christopher A Sarkiss, Alexa Semonche, Michael E Ivan, Ricardo J Komotar
Neuro-Oncology Practice.2020; 7(1): 94.CrossRef
OAR sparing 3D radiotherapy planning supported by fMRI brain mapping investigations
Gábor Opposits, Csaba Aranyi, Csaba Glavák, Zsolt Cselik, Lajos Trón, Dávid Sipos, Janaki Hadjiev, Ervin Berényi, Imre Repa, Miklós Emri, Árpád Kovács
Medical Dosimetry.2020; 45(4): e1.CrossRef
The Role of Navigated Transcranial Magnetic Stimulation Motor Mapping in Adjuvant Radiotherapy Planning in Patients With Supratentorial Brain Metastases
Maximilian J. Schwendner, Nico Sollmann, Christian D. Diehl, Markus Oechsner, Bernhard Meyer, Sandro M. Krieg, Stephanie E. Combs
Frontiers in Oncology.2018;[Epub]CrossRef
Impact of the radiosurgery prescription dose on the local control of small (2 cm or smaller) brain metastases
Alireza M. Mohammadi, Jason L. Schroeder, Lilyana Angelov, Samuel T. Chao, Erin S. Murphy, Jennifer S. Yu, Gennady Neyman, Xuefei Jia, John H. Suh, Gene H. Barnett, Michael A. Vogelbaum
Journal of Neurosurgery.2017; 126(3): 735.CrossRef
Nonthermal ablation in the rat brain using focused ultrasound and an ultrasound contrast agent: long-term effects
Nathan McDannold, Yongzhi Zhang, Natalia Vykhodtseva
Journal of Neurosurgery.2016; 125(6): 1539.CrossRef
Analysis of risk and predictors of brain radiation necrosis after radiosurgery
Hongqing Zhuang, Yi Zheng, Junjie Wang, Joe Y. Chang, Xiaoguang Wang, Zhiyong Yuan, Ping Wang
Oncotarget.2016; 7(7): 7773.CrossRef
Discriminating radiation necrosis from tumor progression in gliomas: a systematic review what is the best imaging modality?
Ashish H. Shah, Brian Snelling, Amade Bregy, Payal R. Patel, Danoushka Tememe, Rita Bhatia, Evelyn Sklar, Ricardo J. Komotar
Journal of Neuro-Oncology.2013; 112(2): 141.CrossRef
Comparison of Swallowing Functions Between Brain Tumor and Stroke Patients
Dae Hwan Park, Min Ho Chun, Sook Joung Lee, Yoon Bum Song
Annals of Rehabilitation Medicine.2013; 37(5): 633.CrossRef

10,349View
60Download
8Crossref

Adenovirus - Mediated gene Transfer of Wild - Type p53 Results in Restoration of Tumor - Suppressor Function in Glioma Cell Lines: Mi Sook Kim, Hee Chung Kwon, Seok Il Hong, Choon Taek Lee, Seung Hoon Lee; J Korean Cancer Assoc. 1998;30(5):1026-1033.

AbstractPDF: PURPOSE
The replacement of functional genes into cells that lack genes or mutant genes is the basis of gene therapy. In cancer, where cells often have multiple genetic defects, the replacement of critical genes may suffice to suppress cell growth or induce cell death. In malignant brain tumors, p53 mutation are among the most frequently observed genetic findings and inactivation p53 suggests that p53 plays a critical role in carcinogenesis and tumor progression.Therefore, we study the successful transfer of the wild-type p53 gene using a replicative deficient adenovirus vector into human glioma and medulloblastoma c~ell lines. Meterials and Methods: The human glioma cell line T-98G, U-87MG, U-373MG were used. To determine the efficiency of the adenovirus vector, cell lines were transfected with the Ad-p gal and analysed with X-Gal staining. Cell viability was determined by trypan blue exclusion every day after infection and Westem blot analysis was used to conform the expression of the exogenous p53 protein.
RESULTS
Cell growth of the Ad-CMV-p53 infected U-373MG, and U-87MG was significantly suppressed. It appeared that exogenous p53 protein expression had an earlier ad more profound suppressive effect on U-373MG having a mutated p53 gene than on U-87MG having a wild-type p53. The expression of the exogenous p53 was more than 10 times higher than the expression of the endogenous p53. To examine the decreased viability, U-373MG was stained with Hochest 33258 and detected nuclear condensation and apoptic body. Staining results suggest that cells undergo apoptosis.
CONCLUSION
The replicative deficient adenoviral vector can transfer and express p53 in human glioma cell lines in vitro, restoring wild-type p53 tumor suppressor functions.The restoration of normal p53-encoded protein in the mutant ceil lines induced cell death. The high expression of the newly transduced protein had different effects on the growth rate of the infected cell lines depending on the p53 status of the cells.

2,056View
13Download

Molecular genetic study of primary malignant brain tumors:loss of heterozygosity on chromosome 10, 13q, 17q and 22q: Seung Hoon Lee, Jong Hyun Kim, Chang Hoon Lee, Young Soon Kang, Je Ho Lee; J Korean Cancer Assoc. 1993;25(5):717-724.

AbstractPDF: No abstract available.

2,335View
12Download